EFFECT OF ZINC SUPPLEMENTATION ON THYROIDAL 131I UPTAKE, RETENTION AND DOSE DELIVERED TO THYROID FROM 131I IN 131I-TREATED FEMALE WISTAR RATS
|ABSTRACTS OF THE PAPERS APPEARING IN VOLUME 53(2003)|
M.S. Baweja, Poonam and D.K. Dhawan
Department of Biophysics, Panjab University, Chandigarh - 160 014
Studies were conducted to elucidate the role of zinc on thyroidal 131I uptake, retention and dose delivered to the thyroids from 0.37 MBq of 131I (carrier-free) administered intraperitoneally after 4-weeks of study. Thirty two female wistar rats were randomly and equally segregated in four treatment groups. Animals in group 1 were kept as normal control. Animals in groups 2 & 4, were administered a dose of 3.7MBq of 131I (carrier-free) intraperitoneally. Groups 3 & 4 animals, received Zinc (as ZnSO4.7H2O) at a dose level of 227mg/L added to their drinking water for a period of 4-weeks. In conclusion, zinc has been found to increase the retention of 131I in thyroid of 131I-treated rats & may be used as an adjuvant to 131I therapy.
Key words: Biokinetics, biological half-life, 131I, radiation dose, rats, thyroid, zinc.