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MOLECULAR DESIGN OF NOVEL CHOLESTERYL LIPIDS FOR THE DELIVERY OF GENES ACROSS THE CELL MEMBRANES

ABSTRACTS OF THE PAPERS APPEARING IN VOLUME 53(2003)
 
Santanu Bhattacharya and Avinash Bajaj
Department of Organic Chemistry, Indian Institute of Science, Bangalore - 560 012

Abstract
Novel cationic cholesterol derivatives with ether and ester linkages between cationic head group and cholesterol backbone have been developed. Their gene transfection efficacies have been tested as mixtures with a helper lipid, dioleoyl phosphatidyl ethanolamine (DOPE). It has been observed that there is an improvement in gene transfection efficacies when cationic head group is linked to cholesterol via an ether type of linkage.

Key words: Genes, influx, membrane, therapy.
 
 
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