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AMELIORATING EFFECTS OF ANTIOXIDANTS AGAINST DOXORUBICIN INDUCED GENOTOXICITY IN TESTIS OF MICE

ABSTRACTS OF THE PAPERS APPEARING IN VOLUME 54(2004)
 
*P. Kaur, J. Soni and P. Sharma
Department of Zoology, Panjab University, Chandigarh - 160 014
*Correspondence Author : pushpindarkaur@yahoo.co.in


Abstract
An antitumor antibiotic, doxorubicin, is used for the treatment of a variety of the soft and solid human malignancies. During the present investigations, ameliorating effects of antioxidants, sesamol and garlic oil, have been tested against genotoxicity of doxorubicin by employing comet assay on the testis of mice (Mus musculus) of laca strain. Two different doses of sesamol and garlic oil were administered to mice for six consecutive days and then a dose of doxorubicin was given. The positive and negative controls were also run for comparison. The mice were tested for their genotoxicity after 24, 48 & 72 hours. Pretreatment with both the antioxidants reduced the sizes of the comets considerably. But the pretreatment of mice with the high dose of garlic oil reduced the mutagenicity of the drug to a considerable extent than sesamol pretreatment.

Key words:Doxorubicin, sesamol, garlic oil, amelioration, comet assay.
 
 
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