Syamala Devi1 and Kalyani2
1. Department of Computer Science and Applications, Panjab University, Chandigarh
2. Indira Gandhi National Open University, New Delhi
*Corresponding author :firstname.lastname@example.org
There is a need for knowing the structure of proteins for various reasons
in biomedical applications. However, the rate at which the structures of
proteins determined is not at par with the sequences of proteins derived.
Therefore, theoretical methods using knowledge based techniques became popular
to predict structures. Bioinformatics techniques are used for sequence alignment
and comparison in the past and several algorithms were used in doing so.
Structure based sequence information will be useful in making a link between
the structure and sequence. In the present paper attempts were made to make
a database of sequences of known secondary structure elements of a popular
protein fold, beta-barrel or TIM-barrel. A string of sequence would be screened
against the database strings to find out the secondary structural score
of the input sequence. Provision has been made to give the input and obtain
the output through a web interface.
Key words:-Bioinformatics, protein structure, secondary structure, structure
prediction, Needleman-Wunsch algorithm, TIM-barrel fold.