Panjab University Research Journal (Science)
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SURFACE ALTERATIONS OF PLACENTA IN PLASMODIUM BERGHEI INFECTED PREGNANT MICE

Geeta Shukla* and Neeraj Pahuja
Department of Microbiology, Panjab University, Chandigarh - 160 014
*Corresponding author : geeta_shukla@pu.ac.in

Abstract
The severity of malaria infection during pregnancy is correlated with the parasitaemic levels, placental infection and foetal abnormalities. Malaria is more severe and frequent in pregnant woman, than in non-pregnant women. Placenta of pregnant Plasmodium berghei infected mice showed alterations on surface of placenta. Trophoblastic membrane of the infected placenta was severely damaged. The bulbous microvillus ends were severely necrosed that resulted in aggregation of trophoblastic membrane. These altered placental surface may be responsible for internal damage of placenta which in turn might be responsible for abnormal foetal developments like pre-term delivery, low body weight of new born, foetal death or abortions in pregnant women.

Key words:. Plasmodium berghei, placenta, pregnancy, malaria..
 

 
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